業績
2023
2022
2021
-
Horisawa-Takada Y, Kodera C, TakemotoK, Sakashita A, Horisawa K, Maeda R, Shimada R, Usuki S, Fujimura S, Tani N, Matsuura K, Akiyama T, Suzuki A, Niwa H, Tachibana M, Ohba T, Katabuchi H, Namekawa SH, Araki K, Ishiguro K.
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
Nat Commun 2021 12(1):3184. [PubMed]
-
Yoshino T, Suzuki T, Nagamatsu G, Yabukami H, Ikegaya M, Kishima M, Kita H, Imamura T, Nakashima K, Nishinakamura R, Tachibana M, Inoue M, Shima Y, Morohashi K, Hayashi K.
Generation of ovarian follicles from mouse pluripotent stem cells.
Science 2021 373(6552):eabe0237. [PubMed]
-
Hashimoto D, Hirashima T, Yamamura H, Kataoka T, Fujimoto K, Hyuga T, Yoshiki A, Kimura K, Kuroki S, Tachibana M, Suzuki K, Yamamoto N, Morioka S, Sasaki T, Yamada G.
Dynamic erectile responses of a novel penile organ model utilizing TPEM.
Biol Reprod 2021 104(4):875-886. [PubMed]
2020
-
Miyawaki S, Kuroki S, Maeda R, Okashita N, Koopman P, Tachibana M.
The mouse Sry locus harbors a cryptic exon that is essential for male sex determination.
Science 2020 370(6512):121-124. [論文説明] [PubMed]各メディアで報道されました。
-
Kuroki S, Maeda R, Kitano S, Miyachi H, Fukuda M, Shinkai Y, Tachibana M.
H3K9 demethylases JMJD1A and JMJD1B control prospermatogonia to spermatogonia transition in mouse germline.
Stem Cell Reports 2020 15(2):424-438.[PubMed] -
- Ideno H, Nakashima K, Komatsu K, Araki R, Abe M, Arai Y, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
G9a is involved in the regulation of critical bone formation through activation of Runx2 function during development.
Bone 2020 137:e115332. [PubMed]
- Ideno H, Nakashima K, Komatsu K, Araki R, Abe M, Arai Y, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
-
- Someda M, Kuroki S, Miyachi H, Tachibana M, Yonehara S.
Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis.
Cell Death Differ 2020 27(5):1539-1553.[PubMed]
- Someda M, Kuroki S, Miyachi H, Tachibana M, Yonehara S.
2019
-
- Okashita N, Kuroki S, Maeda R, Tachibana M.
TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.
Sci Rep 2019 9(1):13462. [PubMed]
- Okashita N, Kuroki S, Maeda R, Tachibana M.
-
- Chen J, Kuroki S, Someda M, Yonehara S.
Interferon-γ Induces the Cell Surface Exposure of Phosphatidylserine by Activating the Protein MLKL in the Absence of caspase-8 Activity.
J Biol Chem 2019 294(32):11994-12006. [PubMed]
- Chen J, Kuroki S, Someda M, Yonehara S.
-
- Au Yeung WK, Brind’Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, Sasaki H.
Histone H3K9 Methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection.
Cell Rep 2019 27(1):282-293.e4. [PubMed]
- Au Yeung WK, Brind’Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, Sasaki H.
-
- Fukuda M, Sakaue-Sawano A, Shimura C, Tachibana M, Miyawaki A, Shinkai Y.
G9a-dependent histone methylation can be induced in G1 phase of cell cycle.
Sci Rep 2019 9(1):956. [PubMed]
- Fukuda M, Sakaue-Sawano A, Shimura C, Tachibana M, Miyawaki A, Shinkai Y.
2018
-
- Tatsumi D, Hayashi Y, Endo M, Kobayashi H, Yoshioka T, Kiso K, Kanno S, Nakai Y, Maeda I, Mochizuki K, Tachibana M, Koseki H, Okuda A, Yasui A, Kono T, Matsui Y.
DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells.
PLoS One 2018 13(11):e0205969. [PubMed]
- Tatsumi D, Hayashi Y, Endo M, Kobayashi H, Yoshioka T, Kiso K, Kanno S, Nakai Y, Maeda I, Mochizuki K, Tachibana M, Koseki H, Okuda A, Yasui A, Kono T, Matsui Y.
-
- Masaki K, Sakai M, Kuroki S, Jo JI, Hoshina K, Fujimori Y, Oka K, Amano T, Yamanaka T, Tachibana M, Tabata Y, Shiozawa T, Ishizuka O, Hochi S, Takashima S.
FGF2 Has Distinct Molecular Functions from GDNF in the Mouse Germline Niche.
Stem Cell Reports 2018 10(6):1782-1792. [PubMed]
- Masaki K, Sakai M, Kuroki S, Jo JI, Hoshina K, Fujimori Y, Oka K, Amano T, Yamanaka T, Tachibana M, Tabata Y, Shiozawa T, Ishizuka O, Hochi S, Takashima S.
-
Kuroki S, Nakai Y, Maeda R, Okashita N, Akiyoshi M, Yamaguchi Y, Kitano S, Miyachi H, Nakato R, Ichiyanagi K, Shirahige K, Kimura H, Shinkai Y, Tachibana M.
Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.Stem Cell Reports 2018 10(4):1340-1354. [PubMed]
2017
-
- Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K.
Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.
Oncogene 2017 36(45):6262-6271. [PubMed]
- Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K.
-
- Kuroki S, Okashita N, Baba S, Maeda R, Miyawaki S, Yano M, Yamaguchi M, Kitano S, Miyachi H, Itoh A, Yoshida M, Tachibana M.
Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.
PLoS Genet 2017 13(9):e1007034. [PubMed]
- Kuroki S, Okashita N, Baba S, Maeda R, Miyawaki S, Yano M, Yamaguchi M, Kitano S, Miyachi H, Itoh A, Yoshida M, Tachibana M.
-
- Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
Essential roles of G9a in cell proliferation and differentiation during tooth development.
Exp Cell Res 2017 357(2):202-210. [PubMed]
- Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
2016
-
- Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y.
PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.
Stem Cell Reports 2016 7(6):1072-1086. [PubMed]
- Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y.
-
- Muramatsu D, Kimura H, Kotoshiba K, Tachibana M, Shinkai Y.
Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1.
Cell Struct Funct 2016 41(2):145-152. [PubMed]
- Muramatsu D, Kimura H, Kotoshiba K, Tachibana M, Shinkai Y.
-
- Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ.
HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.
Proc Natl Acad Sci U S A 2016 113(46):E7212-E7221. [PubMed]
- Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ.
2015
-
- Wada S, Ideno H, Shimada A, Kamiunten T, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro.
Histochem Cell Biol 2015 144(1):13-20. [PubMed]
- Wada S, Ideno H, Shimada A, Kamiunten T, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
-
- Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.
Genesis 2015 53(6):387-93. [PubMed]
- Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
2014
-
- Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H, Poellinger L.
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Mol Cell Biol 2014 34(19):3702-20. [PubMed]
- Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H, Poellinger L.
-
- Warr N, Siggers P, Carré GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Teboul L, Wells S, Sanderson J, Greenfield A.
Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.
Hum Mol Genet 2014 23(11):3035-44. [PubMed]
- Warr N, Siggers P, Carré GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Teboul L, Wells S, Sanderson J, Greenfield A.
2013
-
Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M.
Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a.
Science 2013 341(6150):1106-1109 [PubMed]
・ 新聞各紙およびNHKニュースで報道されました。
・ 「ライフサイエンス新着論文レビュー」に解説記事が掲載されました。
・ This paper is recommended by “Faculty of1000” -
- Kuroki S, Akiyoshi M, Tokura M, Miyachi H, Nakai Y, Kimura H, Shinkai Y, Tachibana M.
JMJD1C, a JmjC Domain-Containing Protein, Is Required for Long-Term Maintenance of Male Germ Cells in Mice.
Biol Reprod 2013 Sep 4. [PubMed]
- Kuroki S, Akiyoshi M, Tokura M, Miyachi H, Nakai Y, Kimura H, Shinkai Y, Tachibana M.
-
- Muramatsu D, Singh PB, Kimura H, Tachibana M, Shinkai Y.
Pericentric Heterochromatin Generated by HP1 Protein Interaction-defective Histone Methyltransferase Suv39h1.
J Biol Chem 2013 288(35):25285-96. [PubMed]
- Muramatsu D, Singh PB, Kimura H, Tachibana M, Shinkai Y.
-
- Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M,Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R.
Homeoproteins six1 and six4 regulate male sex determination and mouse gonadal development.
Dev Cell 2013 26(4):416-30. [PubMed]
- Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M,Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R.
-
- Ohno R, Nakayama M, Naruse C, Okashita N, Takano O, Tachibana M, Asano M, Saitou M, Seki Y.
A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.
Development 2013 140(14):2892-903. [PubMed]
- Ohno R, Nakayama M, Naruse C, Okashita N, Takano O, Tachibana M, Asano M, Saitou M, Seki Y.
-
- Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T.
Histone H3 lysine 9 methyltransferases,G9a and GLP are essential for cardiac morphogenesis.
Mech Dev 2013 Jul 24. [PubMed]
- Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T.
-
- Balemans MC, Nadif Kasri N, Kopanitsa MV, Afinowi NO, Ramakers G, Peters TA, Beynon AJ, Janssen SM, van Summeren RC, Eeftens JM, Eikelenboom N, Benevento M, Tachibana M, Shinkai Y, Kleefstra T, van Bokhoven H, Van der Zee CE.
Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome.
Hum Mol Genet 2013 22(5):852-66. [PubMed]
- Balemans MC, Nadif Kasri N, Kopanitsa MV, Afinowi NO, Ramakers G, Peters TA, Beynon AJ, Janssen SM, van Summeren RC, Eeftens JM, Eikelenboom N, Benevento M, Tachibana M, Shinkai Y, Kleefstra T, van Bokhoven H, Van der Zee CE.
-
- Deguchi K, Nagamatsu G, Miyachi H, Kato Y, Morita S, Kimura H, Kitano S, Hatada I, Saga Y, Tachibana M, Shinkai Y.
Posttranscriptional Regulation ofHistone Lysine Methyltransferase GLP in Embryonic Male Mouse Germ Cells.
Biol Reprod 2013 88(2):36. [PubMed]
- Deguchi K, Nagamatsu G, Miyachi H, Kato Y, Morita S, Kimura H, Kitano S, Hatada I, Saga Y, Tachibana M, Shinkai Y.
2012
-
- Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamashita JK.
Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a.
Cell Stem Cell. 2012 Jun 14;10(6):759-70. [PubMed]
- Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamashita JK.
-
- Nakamura T, Liu YJ, Nakashima H, Umehara H, Inoue K, Matoba S, Tachibana M, Ogura A, Shinkai Y, Nakano T.
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.
Nature. 2012 Jun 3;486(7403):415-9. [PubMed]
- Nakamura T, Liu YJ, Nakashima H, Umehara H, Inoue K, Matoba S, Tachibana M, Ogura A, Shinkai Y, Nakano T.
-
- Takahashi M, Takemoto Y, Shimazu T, Kawasaki H, Tachibana M, Shinkai Y, Takagi M, Shin-ya K, Igarashi Y, Ito A, Yoshida M.
Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.
J Antibiot (Tokyo). 2012 May;65(5):263-5. [PubMed]
- Takahashi M, Takemoto Y, Shimazu T, Kawasaki H, Tachibana M, Shinkai Y, Takagi M, Shin-ya K, Igarashi Y, Ito A, Yoshida M.
-
- Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G, Saya H, Hara E.
DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells.
Mol Cell. 2012 Jan 13;45(1):123-31. [PubMed]
- Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G, Saya H, Hara E.
2011
-
- Takada Y, Naruse C, Costa Y, Shirakawa T, Tachibana M, Sharif J, Kezuka-Shiotani F, Kakiuchi D, Masumoto H, Shinkai Y, Ohbo K, Peters AH, Turner JM, Asano M, Koseki H.
HP1γ links histone methylation marks to meiotic synapsis in mice.
Development. 2011 Oct;138(19):4207-17. [PubMed]
- Takada Y, Naruse C, Costa Y, Shirakawa T, Tachibana M, Sharif J, Kezuka-Shiotani F, Kakiuchi D, Masumoto H, Shinkai Y, Ohbo K, Peters AH, Turner JM, Asano M, Koseki H.
-
- Hayashi-Takanaka Y, Yamagata K, Wakayama T, Stasevich TJ, Kainuma T, Tsurimoto T, Tachibana M, Shinkai Y, Kurumizaka H, Nozaki N, Kimura H.
Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling.
Nucleic Acids Res. 2011 Aug;39(15):6475-88. [PubMed]
- Hayashi-Takanaka Y, Yamagata K, Wakayama T, Stasevich TJ, Kainuma T, Tsurimoto T, Tachibana M, Shinkai Y, Kurumizaka H, Nozaki N, Kimura H.
-
- Shinkai Y, Tachibana M.
H3K9 methyltransferase G9a and the related molecule GLP
Genes Dev. 2011 Apr 15;25(8):781-8. [PubMed]
- Shinkai Y, Tachibana M.
-
- Leung, D. Dong, K. Maksakova, I. Goyal, P. Appanah, R. Lee, S. Tachibana, M. Shinkai, Y. Lehnertz, B. Mager, D. Rossi, F. and Lorincz, M.C.*.
Lysine methyltransferase G9a is required for de novo DNA methylation and establishment but not maintenance of proviral silencing.
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5718-23. [PubMed]
- Leung, D. Dong, K. Maksakova, I. Goyal, P. Appanah, R. Lee, S. Tachibana, M. Shinkai, Y. Lehnertz, B. Mager, D. Rossi, F. and Lorincz, M.C.*.
2010
-
- Balemans, M*. Huibers, M. Eikelenboom, N. Kuipers, A. van Summeren, R. Pijpers, M. Tachibana, M. Shinkai, Y. van Bokhoven, H. and van der Zee, C.E..
Reduced exploration, increased anxiety, and altered social behavior: autistic-like features in Ehmt1+/- mice.
Behav Brain Res. 2010 Mar 17;208(1):47-55. [PubMed]
- Balemans, M*. Huibers, M. Eikelenboom, N. Kuipers, A. van Summeren, R. Pijpers, M. Tachibana, M. Shinkai, Y. van Bokhoven, H. and van der Zee, C.E..
-
- Hashimoto H, Takami Y, Sonoda E, Iwasaki T, Iwano H, Tachibana M, Takeda S, Nakayama T, Kimura H, Shinkai Y*.
Histone H1 null vertebrate cells exhibit altered nucleosome architecture.
Nucleic Acids Res. 2010 Jun;38(11):3533-45. [PubMed]
- Hashimoto H, Takami Y, Sonoda E, Iwasaki T, Iwano H, Tachibana M, Takeda S, Nakayama T, Kimura H, Shinkai Y*.
-
- Matsui T#, Leung D#, Miyashita H, Maksakova IA, Miyachi H, Kimura H, Tachibana M, Lorincz MC*, Shinkai Y*.
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.
Nature. 2010 Apr 8;464(7290):927-31. [PubMed]
- Matsui T#, Leung D#, Miyashita H, Maksakova IA, Miyachi H, Kimura H, Tachibana M, Lorincz MC*, Shinkai Y*.
2009
-
- Yokochi T. Poduch K. Ryba T. Lu J. Hiratani T. Tachibana M. Shinkai Y.and Gilbert D.M*.
G9a selectively represses a class of late-replicating genes at the nuclear periphery.
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19363-8. [PubMed]
- Yokochi T. Poduch K. Ryba T. Lu J. Hiratani T. Tachibana M. Shinkai Y.and Gilbert D.M*.
-
- Inagaki, T#. Tachibana, M#. Magoori, K. Kudo, H. Tanaka, T. Okamura, M. Naito, M. Kodama, T. Shinkai, Y*. and Sakai , Y*.
Obesity and metabolic syndrome in histone demethylase JHDM2a deficient mice.
Genes to Cells, 2009 Aug;14(8):991-1001. (#equal contribution) [PubMed]
- Inagaki, T#. Tachibana, M#. Magoori, K. Kudo, H. Tanaka, T. Okamura, M. Naito, M. Kodama, T. Shinkai, Y*. and Sakai , Y*.
-
- Link, P. Gangisetty, O.James, S. Woloszynska-Read, A. Tachibana, M. Shinkai, Y. Karpf, A*.
Distinct Roles for Histone Methyltransferases G9a and GLP in Cancer Germ-Line Antigen Gene Regulation in Human Cancer Cells and Murine Embryonic Stem Cells.
Mol Cancer Res. 2009 Jun;7(6):851-62. [PubMed]
- Link, P. Gangisetty, O.James, S. Woloszynska-Read, A. Tachibana, M. Shinkai, Y. Karpf, A*.
-
- Shirato, H. Ogawa, S. Nakajima , K. Inagawa, M. Kojima, M. Tachibana, M. Shinkai, Y. and Takeuchi, T*.
A Jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.
J Biol Chem.2009 Jan 9;284(2):733-9. [PubMed]
- Shirato, H. Ogawa, S. Nakajima , K. Inagawa, M. Kojima, M. Tachibana, M. Shinkai, Y. and Takeuchi, T*.
2008
-
- Tachibana M*. Matsumura Y. Fukuda M. Kimura H. and Shinkai Y*.
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.
EMBO J. 2008 Oct 22;27(20):2681-90. [PubMed]
- Tachibana M*. Matsumura Y. Fukuda M. Kimura H. and Shinkai Y*.
-
- Dong KB, Maksakova IA, Mohn F, Leung D, Appanah R, Lee S, Yang HW, Lam LL, Mager DL, Schubeler D, Tachibana M, Shinkai Y, Lorincz MC.*
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity.
EMBO J. 2008 Oct 22;27(20):2691-701. [PubMed]
- Dong KB, Maksakova IA, Mohn F, Leung D, Appanah R, Lee S, Yang HW, Lam LL, Mager DL, Schubeler D, Tachibana M, Shinkai Y, Lorincz MC.*
-
- Okamoto K. Iwano T. Tachibana M. and Shinkai Y*.
Distinct roles of TRF1 in the regulation of telomere structure and lengthening.
J. Biol. Chem., 2008 Aug 29;283(35):23981-8. [PubMed]
- Okamoto K. Iwano T. Tachibana M. and Shinkai Y*.
-
- Thomas, L.R. Miyashita, H. Cobb, R.M. Pierce S. Tachibana, M. Hobeika, E. Reth, M. Shinkai, Y. and Oltz, E.M*.
Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes.
J.Immunol. 2008 Jul 1;181(1):485-93. [PubMed]
- Thomas, L.R. Miyashita, H. Cobb, R.M. Pierce S. Tachibana, M. Hobeika, E. Reth, M. Shinkai, Y. and Oltz, E.M*.
-
- Kato, Y. Kato, M. Tachibana, M. Shinkai, Y. and Yamaguchi, M*.
Characterization of Drosophila G9a in vivo and identification of genetic interactions.
Genes to Cells. 2008 Jul;13(7):703-22. [PubMed]
- Kato, Y. Kato, M. Tachibana, M. Shinkai, Y. and Yamaguchi, M*.
2007
-
- Hashimoto, H. Sonoda, E. Takami, Y. Kimura, H. Nakayama, T. Tachibana, M. Takeda, S. and Shinkai, Y*.
Histone H1 variant, H1R is involved in DNA damage response.
DNA repair, 2007 Nov;6(11):1584-95. [PubMed]
- Hashimoto, H. Sonoda, E. Takami, Y. Kimura, H. Nakayama, T. Tachibana, M. Takeda, S. and Shinkai, Y*.
-
- Tachibana, M*. Nozaki, M. Takeda, N. and Shinkai, Y*.
Functional Dynamics of H3K9 Methylation During Meiotic Prophase Progression.
EMBO J. 2007 Jul 25;26(14):3346-59. [PubMed]
- Tachibana, M*. Nozaki, M. Takeda, N. and Shinkai, Y*.
-
- Nishida, M. Kato, M. Kato, Y. Sasai, N. Ueda, J. Tachibana, M. Shinkai, Y. and Yamaguchi M*.
Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a.
Genes to Cells, 2007 Jul;12(7):877-88. [PubMed]
- Nishida, M. Kato, M. Kato, Y. Sasai, N. Ueda, J. Tachibana, M. Shinkai, Y. and Yamaguchi M*.
-
- Seki, Y. Yamaji, M. Yabuta, Y. Sano, M. Shigeta, M. Tachibana, M. Matsui, Y. Saga, Y. Shinkai, Y. and Saitou, M*.
Cellular dynamics associated with the genome-wide epigenetic reprogramming in primordial germ cells in mice.
Development, 2007 Jul;134(14):2627-38. [PubMed]
- Seki, Y. Yamaji, M. Yabuta, Y. Sano, M. Shigeta, M. Tachibana, M. Matsui, Y. Saga, Y. Shinkai, Y. and Saitou, M*.
-
- Ikegami, K. Iwatani, M. Suzuki, M. Tachibana, M. Shinkai, Y. Tanaka, S. Greally, J.M. Yagi, S. Hattori, N. and Shiota, K*.
Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells.
Genes to Cells, 2007 Jan;12(1):1-11. [PubMed]
- Ikegami, K. Iwatani, M. Suzuki, M. Tachibana, M. Shinkai, Y. Tanaka, S. Greally, J.M. Yagi, S. Hattori, N. and Shiota, K*.
2006
-
- Akiyama, K. Yusa, K. Hashimoto, H. Poonepalli, A. Hande, M.P. Kakazu, N. Takeda, J. Tachibana, M. and Shinkai, Y*.
Rad54 is dispensable for the ALT pathway.
Genes to Cells, 2006 Nov;11(11):1305-15. [PubMed]
- Akiyama, K. Yusa, K. Hashimoto, H. Poonepalli, A. Hande, M.P. Kakazu, N. Takeda, J. Tachibana, M. and Shinkai, Y*.
-
- Ueda J.Tachibana, M. Ikura, T. and Shinkai, Y.
Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
J Biol Chem. 2006 Jul 21;281(29):20120-8. [PubMed]
- Ueda J.Tachibana, M. Ikura, T. and Shinkai, Y.
2005
-
- Tachibana, M. Ueda, J. Fukuda, M. Takeda, N. Ohta, T. Iwanari, H. Sakihama, T. Kodama, T. Hamakubo, T. and Shinkai, Y.
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Genes Dev. 2005 Apr 1;19(7):815-26. [PubMed]
- Tachibana, M. Ueda, J. Fukuda, M. Takeda, N. Ohta, T. Iwanari, H. Sakihama, T. Kodama, T. Hamakubo, T. and Shinkai, Y.
-
- Collins, R.E. Tachibana, M. Tamaru, H. Smith, K.M. Jia, D. Zhang, X. Selker, E.U. Shinkai, Y. and Cheng, X.
In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases.
J Biol Chem. 2005 Feb 18;280(7):5563-70. [PubMed]
- Collins, R.E. Tachibana, M. Tamaru, H. Smith, K.M. Jia, D. Zhang, X. Selker, E.U. Shinkai, Y. and Cheng, X.
2004
-
Ohhata, T. Tachibana, M. Tada, M. Tada, T. Sasaki, H. Shinkai, Y. and Sado, T.
X-inactivation is stably maintained in mouse embryos deficient for G9a.
Genesis. 2004 Nov;40(3):151-6. [PubMed] -
- Osipovitch, O. Meade, A. Milley, R. Oestreich, K. Tachibana, M. Shinkai, Y. Krangel, M.S. and Oltz, E.M.
Targeted inhibition of V(D)J recombination by a histone methyltransferase.
Nat Immunol. 2004 Mar;5(3):309-16. [PubMed]
- Osipovitch, O. Meade, A. Milley, R. Oestreich, K. Tachibana, M. Shinkai, Y. Krangel, M.S. and Oltz, E.M.
-
- Iwano T, Tachibana M, Reth M, Shinkai Y.
Importance of TRF1 for functional telomere structure.
J Biol Chem. 2004 Jan 9; 279(2): 1442-8. [PubMed]
- Iwano T, Tachibana M, Reth M, Shinkai Y.
2003
-
- Peters, A. Kubicek, S. Mechtler, K. O’ Sullivan, R.J. Derijck, A.A. Perez-Burgos, L. Kohlmaier, A. Opravil, S. Tachibana, M. Shinkai, Y. Martens, J.H. and Jenuwein, T*.
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
Mol Cell. 2003 Dec;12(6):1577-89. [PubMed]
- Peters, A. Kubicek, S. Mechtler, K. O’ Sullivan, R.J. Derijck, A.A. Perez-Burgos, L. Kohlmaier, A. Opravil, S. Tachibana, M. Shinkai, Y. Martens, J.H. and Jenuwein, T*.
-
- Fujita N, Watanabe S, Ichimura T, Tsuruzoe S, Shinkai Y, Tachibana M, Chiba T, Nakao M.
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.
J Biol Chem. 2003 Jun 27;278(26):24132-8. [PubMed]
- Fujita N, Watanabe S, Ichimura T, Tsuruzoe S, Shinkai Y, Tachibana M, Chiba T, Nakao M.
-
- Xin, Z. Tachibana, M. Guggiari, M. Heard, E. Shinkai, Y. and Wagstaff, J.
Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center.
J Biol Chem. 2003 Apr 25;278(17):14996-5000. [PubMed]
- Xin, Z. Tachibana, M. Guggiari, M. Heard, E. Shinkai, Y. and Wagstaff, J.
2002
-
- Tachibana, M. Sugimoto, K. Nozaki, M. Ueda, J. Ohta, T. Ohki, M. Fukuda, M. Takeda, N. Niida, H. Kato, H. and Shinkai, Y.
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
Genes Dev. 2002 Jul 15;16(14):1779-91. [PubMed]
- Tachibana, M. Sugimoto, K. Nozaki, M. Ueda, J. Ohta, T. Ohki, M. Fukuda, M. Takeda, N. Niida, H. Kato, H. and Shinkai, Y.
2001
-
- Tachibana, M. Narumi, O. Muguruma, K. Yamamoto, I. Shinkai, Y. and Yokota, Y.
Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23).
Cytogenet Cell Genet. 2001;94(1-2):23-5. [PubMed]
- Tachibana, M. Narumi, O. Muguruma, K. Yamamoto, I. Shinkai, Y. and Yokota, Y.
-
- Ono, Y. Shimozawa, N. Kimoto, S. Tachibana, M. Shinkai, Y. Ito, M. and Kono, T.
Production of cloned mice from embryonic stem cells arrested at metaphase.
Reproduction. 2001 Nov;122(5):731-6. [PubMed]
- Ono, Y. Shimozawa, N. Kimoto, S. Tachibana, M. Shinkai, Y. Ito, M. and Kono, T.
-
- Tachibana, M. Sugimoto, K. Fukushima, T. and Shinkai, Y.
SET-domain containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.
J Biol Chem. 2001 Jul 6;276(27):25309-17. [PubMed]
- Tachibana, M. Sugimoto, K. Fukushima, T. and Shinkai, Y.
2000
-
- Wakayama, T. Shinkai, Y. Tamashiro, K.L.K. Niida, H. Blanchard, C.D. Blanchard, R.J. Ogura, A. Tanemura, K. Tachibana, M. Perry, A.C.F. Monbaerts, P. and Yanagimachi, R.
Cloning of mice to six generations.
Nature. 2000 Sep 21;407(6802):318-9. [PubMed]
- Wakayama, T. Shinkai, Y. Tamashiro, K.L.K. Niida, H. Blanchard, C.D. Blanchard, R.J. Ogura, A. Tanemura, K. Tachibana, M. Perry, A.C.F. Monbaerts, P. and Yanagimachi, R.
-
- Tachibana M, Siddiqi MA, Ikegami Y, Eshima K, Shirota-Someya Y, Tahara-Hanaoka S, Koito A, Iizuka M, Shinohara N.
Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus.
J Biol Chem. 2000 Jul 7;275(27):20288-94. [PubMed]
- Tachibana M, Siddiqi MA, Ikegami Y, Eshima K, Shirota-Someya Y, Tahara-Hanaoka S, Koito A, Iizuka M, Shinohara N.
-
- Niida, H. Shinkai, Y*. Hande, M.P. Matsumoto, T. Takehara, S. Tachibana, M. Oshimura, M. Lansdorp, P.M. and Furuichi, Y.
Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA.
Mol Cell Biol. 2000 Jun;20(11):4115-27. [PubMed]
- Niida, H. Shinkai, Y*. Hande, M.P. Matsumoto, T. Takehara, S. Tachibana, M. Oshimura, M. Lansdorp, P.M. and Furuichi, Y.
1998
-
- Senoo, M. Seki, N. Ohira, M. Sugano, S. Watanabe, M. Tachibana, M. Tanaka, T. Shinkai, Y* . and Kato, H*.
A second p53-related protein, p73L, with high homology to p73.
Biochem Biophys Res Commun. 1998 Jul 30;248(3):603-7. [PubMed]
- Senoo, M. Seki, N. Ohira, M. Sugano, S. Watanabe, M. Tachibana, M. Tanaka, T. Shinkai, Y* . and Kato, H*.
総説
-
2021
Okashita N, Tachibana M.
Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY.
Sex Dev 2021 15(5-6):351-359. [PubMed]
-
2019
Miyawaki S, Tachibana M.
Role of epigenetic regulation in mammalian sex determination.
Curr Top Dev Biol 2019 134:195-221. [PubMed] -
2017
Kuroki S, Tachibana M.
Epigenetic regulation of mammalian sex determination.
Mol Cell Endocrinol 2017 468:31-38. [PubMed] -
2016
Tachibana M.
Epigenetics of Sex Determination in Mammals.
Reproductive Medicine and Biology 2016 15:59-67. [PubMed]Tachibana M.
Epigenetics of sex determination in mammals.
Reprod Med Biol 2016 15(2):59-67. [PubMed] -
2015
Tachibana M.
Epigenetic regulation of mammalian sex determination.
J Med Invest 2015 62(1-2):19-23. [PubMed] -
2013
- 立花 誠
「エピジェネティクスの側面から見た哺乳類の性分化」
細胞工学，Vol.32，No.2，p180-192，2013．
- 立花 誠
-
2011
- Shinkai, Y. and Tachibana, M.
H3K9 methyltransferase G9a and the related molecule GLP.
Gene Dev 2011 25(8):781-8. [PubMed]
- Shinkai, Y. and Tachibana, M.
-
2008
- 立花 誠
「ヒストン修飾抗体を用いたウエスタンブロット解析」
実験医学別冊、エピジェネティクス実験プロトコール、p134-142,羊土社, 2008
- 立花 誠
-
2007
- 立花 誠
「ヒストンリジンメチル化による生命機能の制御」
実験医学、vol.25-No.10, 2007,1505-1509
- 立花 誠，眞貝 洋一
「ヒストンのメチル化による生殖細胞の分化制御」
蛋白質 核酸 酵素 vol.52-No.16 p2157-2162, 2007
- 立花 誠
-
2006
- 立花 誠
「ヒストンメチル化の生化学」
生化学、第78巻、2006、50-53
- 立花 誠
-
2005
- 立花 誠
「ヒストンを用いたメチル化検出と、ヒストンメチル化酵素活性測定」
実験医学別冊、タンパク質の翻訳後修飾解析プロトコール、2005, 180-185
- 立花 誠
「哺乳類におけるコアヒストンの転写抑制的なメチル化修飾とエピジェネティクス」
ゲノム医学、vol.5-No.5 2005, 437-442
- 立花 誠
-
2004
- 立花 誠，眞貝 洋一
｢ヒストンH3リジン残基のメチル化修飾による転写制御｣
実験医学，Vol.22，No.9，p1246-1251，羊土社，2004．
- 立花 誠
｢哺乳類ヒストンメチル化酵素、G9aの機能｣
日本農芸化学会誌、vol.78，No.1，p31-33，2004．
- 立花 誠，眞貝 洋一
-
2003
立花 誠
｢ヒストンのメチル化修飾とエピジェネティクス｣
現代医療 『特集･Epigeneticsと疾患』 Vol.35，No.5，p957-963， 現代医療社，2003 -
2002年以前
立花 誠，眞貝 洋一
｢哺乳類細胞のテロメア維持機構｣
実験医学･増刊 『幹細胞研究の最前線と再生医療への応用』 Vol.19，No. 15，p2107-2111，羊土社，2001．